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Gather the ingredients.
Heat the oven to 350 F. Grease a 2-quart casserole dish or spray it with nonstick cooking spray.
Cover the bottom of the casserole with half of the crushed Doritos, about 2 cups.
In a large bowl, combine the diced cooked chicken, sour cream, condensed soup, onion, chili powder, garlic powder, salt, and pepper.
Spoon the chicken mixture on top of the crushed Doritos in the casserole.
Sprinkle the remaining crushed chips over the chicken mixture and then top with the shredded mozzarella and cheddar cheeses.
Bake the casserole in the preheated oven for 30 to 40 minutes, or until the topping is melted and lightly browned.
Serve and enjoy.