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Originally made as a lunch for coal miners, pepperoni rolls are today a beloved snack and appetizer throughout West Virginia. Learn how to make West Virginia's famous pepperoni rolls using frozen roll dough.
Prepare oven and pan: Preheat oven to 400°F. Line a baking sheet with parchment paper.
Make rolls: Working in batches as needed, pat or roll each dough ball on a large piece of wax or parchment paper into a 4 1/4- to 4 1/2-inch round. (Try not to flour dough surface; it could keep dough from sealing.) Place 2 pepperoni slices in middle of each dough round. Tear cheese into pieces, and arrange evenly over pepperoni. Roll up dough jellyroll style; pinch ends and seams well to seal.
Bake rolls: Arrange dough, seam side down, 1 to 1 1/2 inches apart on prepared baking sheet. Brush 2 tablespoons of the butter evenly over rolls. Bake in preheated oven until golden brown, 10 to 12 minutes.
Brush on butter mixture: Stir together garlic powder, oregano, salt, and remaining 2 tablespoons butter in a small bowl until combined. Immediately brush butter mixture evenly over warm rolls. Serve immediately.